Multimodal Neuroimaging of Treatment Effects in Adolescent Mania
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
Specific Aim 1: To determine the effects of treatment with quetiapine or lithium on brain
activation in adolescents. The investigators will use functional magnetic resonance imaging
(fMRI) to examine brain activation during an attentional task.
Specific Aim 2: To determine the effects of treatment with quetiapine or lithium on
neurometabolite measures, early in their illness course. The investigators will use 1H-MRS to
identify myo-inositol (mI), N-acetyl aspartate (NAA), and glutamate (Glu) levels in
prefrontal ALN regions.
Specific Aim 3: To determine the relationships among the changes in brain activation and
neurometabolite measures, as well as symptomatic improvement in manic adolescents.