Multimodal Cue Exposure Therapy for Smoking Cessation
Status:
Withdrawn
Trial end date:
2021-01-31
Target enrollment:
Participant gender:
Summary
At two sites (Boston University and the University of Texas at Austin, under the MPI
direction of Drs. Otto and Smits) the investigators propose to randomly assign 240 adult
smokers who have achieved short-term abstinence following open treatment with a 4 session
cognitive-behavior therapy program combined with medication (nicotine patch, varenicline, or
bupropion, selected openly) to (1) d-cycloserine augmentation of multimodal cue exposure
therapy (CET), or (2) placebo augmentation of multimodal CET. This Stage II project is
designed to: (1) evaluate the short-term and long-term efficacy of the experimental
intervention, (2) further test putative mechanisms of change, (3) explore possible moderator
effects of theoretically-relevant variables, and (4) use innovative, multimodal CET
strategies. Putative mediators and smoking abstinence will be assessed during the
intervention period and up to 6 months following the quit attempt.