Multicentre Canadian Study to Measure the Safety and Efficacy of Radiosynoviorthesis
Status:
Completed
Trial end date:
2018-12-31
Target enrollment:
Participant gender:
Summary
Radiation synovectomy by intra-articular injection of beta-emitting radionuclides is
considered a reliable and easy-to-perform therapy without harmful side-effects for the
treatment of inflammatory joint disease in many countries.
The goal of this study is to demonstrate Yttrium-90 citrate colloid or Rhenium-186 sulfide
synovectomy are appropriate therapeutic interventions in patients with persistent active
synovitis of a joint (characterized by pain, tenderness, and effusion) which is resistant to
systemic therapy and intra-articular corticosteroid injections.
The primary objective will be to assess the safety of an intra-articular administration of
Yttrium-90 citrate colloid or Rhenium-186 sulfide.
The secondary objective will be to assess the efficacy on synovitis.
Phase:
Phase 3
Details
Lead Sponsor:
Centre de recherche du Centre hospitalier universitaire de Sherbrooke