Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
The proposed protocol is a multi-site double-blind, placebo-controlled outpatient study of
the safety and efficacy of Adderall-XR (MAS-ER) and topiramate in the treatment of cocaine
dependence. 198 patients will be enrolled and 176 patients randomized in a 14-week trial. The
proportion of participants achieving sustained cocaine abstinence for three consecutive weeks
at the end of the study will be significantly greater for the combined pharmacotherapies
group compared to the placebo group.