Multicenter Study to Perioperative Chemotherapy for Resectable Adenocarcinoma in Gastric Cancer
Status:
Unknown status
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
The rationale of the NEO-FLOT-trial consists of an intensification of the neoadjuvant
treatment.
This strategy is based upon the clear advantage of perioperative treatment and the fact, that
in former trials adjuvant treatment could only be given in half of the patients (Cunningham
2006, Boige 2007).
In this study neoadjuvant chemotherapy is applied during a period of 12 weeks with an interim
staging after 6 weeks.Due to the favourable efficacy and toxicity data the FLOT-regimen was
chosen for the neoadjuvant treatment consisting of oxaliplatin, docetaxel, folinic acid and
5-Fluorouracil (Al-Batran 2008).
Postoperative treatment according to the results of the MAGIC trail is not part of the trail
and is given at the responsibility of the participating centres.