Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance
Status:
Completed
Trial end date:
2019-03-20
Target enrollment:
Participant gender:
Summary
This is a substudy to a randomised trial investigating the effect of liraglutide on body
weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864). In
the parent trial, patients will be subjected to an 8-week diet intervention phase including a
low-calorie diet and dietetic counseling, after which patients will be randomised to receive
either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on
re-introducing regular foods and a focus on continued motivation to engage in a healthy
lifestyle.
This substudy aims to investigate the impact of, and subsequent change of, joint
inflammation, articular cartilage composition, overall knee morphology, and clinical
symptoms, in obese patients with knee osteoarthritis following a randomisation to Liraglutide
3 mg or Liraglutide 3 mg placebo treatment between weeks 0-52.