Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks

• Status: Active, not recruiting
• Trial end date: 2023-04-16
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study will be to compare the effects of morphine versus ketamine when they are used as adjuvants to the local anesthetic in paravertebral nerve blocks performed with the aid of ultrasound. Furthermore, a group of local anesthetic without an adjuvant, will also be compared to the two groups

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aretaieion University Hospital
• Collaborator: KAT General Hospital
• Treatments: Anesthetics; Anesthetics, Local; Ketamine; Morphine

Criteria

Inclusion Criteria:

• patients undergoing elective thoracotomy for any cause

• American Society of Anesthesiologists class I-III (ASA I-III)

Exclusion Criteria:

• known allergy to local anesthetic

• local inflammation

• paravertebral tumor

• severe respiratory distress ( breathing dependence on accessory muscles)

• severe spinal deformities

• severe ipsilateral diaphragmatic paresis

• morbid obesity (BMI>35 kg/m2)

• blood coagulation disorders

• known contraindication for administration of ketamine or morphine

• psychiatric disorders

• severe cardiovascular disease

• systematic use of opioids due to chronic pain

• renal or hepatic failure

• patients who refuse to participate