Overview

Morphine Consumption in Joint Replacement Patients, With or Without Gabapentin Treatment

Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
0
Participant gender:
All
Summary
Total knee arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain int hese patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reducted pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated in total joint arthroplasty patients.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
McMaster University
Collaborator:
Hamilton Health Sciences Corporation
Treatments:
Gabapentin
gamma-Aminobutyric Acid
Morphine
Criteria
Inclusion Criteria:

- participants aged 19-90

- elective single joint, primary total knee arthroplasty

- use of PCA with morphine for postoperative pain control has been discussed and agreed
upon between patient and anesthetist

Exclusion Criteria:

- bilateral total knee arthroplasty

- revision knee arthroplasty

- underlying disease of epilepsy, seizure, or chronic pain syndrome

- active gastrointestinal bleeding within the last 6 months

- history of non-steroidal anti-inflammatory drug (NSAID) induced asthma

- known or suspected history of drug or alcohol abuse

- participant currently takes gabapentin or pregabalin for any reason

- participant currently takes pain medication that is more potency than codeine or
oxycodone (morphine, hydromorphone, meperidine, methadone, fentanyl, including any
long acting narcotics)

- known allergy to study medications: gabapentin, morphine, NSAID, acetaminophen

- unable to tolerate morphine

- liver impairments

- kidney impairment or calculated creatinine clearance by Cockcroft-Gault formula is
<=60ml/min

- pregnancy or breast-feeding

- participant currently receives associated worker's compensation benefits (WSIB)

- participant unable or unwilling to give written or informed consent

- unable to use PCA