Morning Versus Bedtime Dosing of Antihypertensive Medication
Status:
Recruiting
Trial end date:
2023-01-31
Target enrollment:
Participant gender:
Summary
Previous studies have shown that elevated nighttime blood pressure (BP) was more closely
associated with cardiovascular mortality and morbidity than daytime and clinic BPs. With
increasingly advanced technology, not only 24-hour ambulatory but also home BP monitors can
be used to evaluate nighttime BP. The validation study of the Omron HEM 9601T showed that the
wrist-type home BP monitor could be a suitable and reliable tool for the diagnosis and
management of nocturnal hypertension. However, up to now, there is no data on home nighttime
BP in Chinese patients and it is unclear if different dosing time would reduce ambulatory and
home nighttime BPs differently.
The investigators therefore designed a multicenter randomized clinical trial to compare
between morning dosing and bedtime dosing of antihypertensive medications in the difference
in nighttime, daytime and the 24-h BP reductions evaluated by both ambulatory and home BP
monitoring, and in target organ protections.