Overview

Mood Stabilizer-induced Metabolic Abnormalities in Bipolar Disorder

Status:
Recruiting
Trial end date:
2021-07-01
Target enrollment:
0
Participant gender:
All
Summary
The potential effects of microbiota in bipolar disorder (BD) with microbiota-related dysfunction have not yet been explored clinically, and the integration of microbiota and pharmacometabolomic approaches can provide us the identification of the significant effects of mood stabilizers on metabolic homeostasis, treatment response, and cognitive performance. Therefore, we propose to develop the integration of the microbiota and pharmacometabolomics knowledge base about the mood stabilizer-induced metabolic abnormalities in BD patients.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
National Cheng-Kung University Hospital
Treatments:
Valproic Acid
Criteria
Inclusion Criteria:

- Bipolar disorder outpatients (aged 18-65 years) who meet the Diagnostic and
Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) diagnostic criteria and
start to receive valproate (VPA) will be enrolled consecutively by trained
psychiatrists.

Exclusion Criteria:

- Exclude are patients who had DSM-V diagnosis for substance abuse within the past three
months

- Had treated with antibiotics and/or functional foods (probiotics and/or prebiotics)
for at least one month before entering study

- Presence of stomach/gut problems such as chronic diarrhea, constipation, gas,
heartburn, bloating, etc.

- Had an organic mental disorder, mental retardation, dementia, or other diagnosed
neurological illness

- Had a surgical condition or a major physical illness

- Were pregnant or breast-feeding

- Had any concomitant DSM-V Axis I diagnoses together with somatic or neurologic
illnesses interfering psychiatric evaluation.