Objective of the trial is to assess the safety and efficacy of Montelukast in treatment of
Erythema Nodosum leprosum (ENL) reaction in multibacillary leprosy patients either in
combination with prednisolone or alone.
Hypothesis is that montelukast will reduce the severity of ENL reaction in Multibacillary
leprosy patients without causing an unacceptably high incidence of adverse effects.
Design is a multicentre hospital-based single-blind prospective trial for leprosy patients
with ENL reaction. prior written consent will be taken from the patients who will undergo the
trial.
Endpoints are decrease in severity of ENL and absence of new nerve function impairment