Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a monotherapy with a Beta-Lactam is not inferior to an association of a Beta-Lactam and a macrolide in treating adult patients with community-acquired pneumonia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Swiss National Fund for Scientific Research
• Collaborator: University Hospital, Geneva
• Treatments: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; beta-Lactams; Cefuroxime; Cefuroxime axetil; Clarithromycin; Lactams

Criteria

Inclusion Criteria:

• Age >=18 years

• New infiltrate on chest X-ray, unexplained by another disease process

• Presence of at least two of the following findings suggestive of pneumonia: fever or hypothermia, new or increasing cough, sputum production, pleuritic chest pain, tachypnea, dyspnea or focal signs on chest examination

• Need for hospitalization as defined by the emergency physician in charge of the patient

Exclusion Criteria:

• Allergy to one of the study drugs

• Pregnancy

• Severe immunosuppression

• Recent (<14 d) hospitalization, or currently hospitalized since > 48 hours

• Residency in a nursing home

• Previous use of more than 24 hours of any antibiotic

• Severe community-acquired pneumonia