Monoarticular Corticosteroid Injection Versus Systemic Administration in the Treatment of Rheumatoid Arthritis Patients

• Status: Completed
• Trial end date: 2006-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy and safety of intra-articular glucocorticoid injection to its systemic use for treatment of knee synovitis in patients with Rheumatoid Arthritis

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo

Criteria

Inclusion Criteria:

• Rheumatoid Arthritis diagnosed for more than 6 months

• 18 and 65 years

• Functional class II or III according to the ACR criteria

• VAS for knee pain higher than 5

• Use of stable doses of oral corticosteroid for the last 30 days

• Use of stable doses of DMARDs for the last 3 months

• Active synovitis at least in one knee for at least the 30 days

Exclusion Criteria:

• Non-controlled diabetes mellitus or hypertension

• Bacterial infection of any site

• Blood coagulation disorders

• Skin lesion on the affected knee

• History of previous surgical procedure in the knee

• Use of intra-muscular glucocorticoid in the last 30 days

• Intra-articular injection in the last 3 months

• Knee injection in the last 6 months