Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol For Chronic Subdural Hematoma

• Status: Recruiting
• Trial end date: 2022-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Inadequate sedation and analgesia indicated by intraoperative movements are markers of inadequate MAC during burr-hole surgery for chronic subdural hematoma evacuation especially when general anesthesia poses high risk for the patients.

Dexmedetomidine, ketamine, propofol intravenous infusion and other agents was used to provide monitored anesthesia care with variable success if used as solitary agents as each drug has its limited use.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zagazig University
• Treatments: Dexmedetomidine; Ketamine; Propofol

Criteria

Inclusion Criteria:

• Patient acceptance.

• Both sex.

• Age (50-80) years old.

• Patient with Body Mass Index (BMI) (25-30kg/m²).

• American Society of Anesthesiologist (ASA) II / III

• patient scheduled to burr-hole surgery for chronic subdural hematoma evacuation under MAC.

• Markwalder's Neurological Grading scale (MNGs) score <2.

Exclusion Criteria:

• Patient with difficult airway (mallapati III,IV).

• Altered mental status (psychiatric and anexity disorder).

• Post-traumatic stress disorders.

• History of allergy to study drugs.

• Patient on sedative or hypnotic medication.

• Patients with on painkiller.

• Patients with any degree of heart block.

• Sever liver, respiratory or renal impairment.