Overview

Molecular Detection of Antibiotic Resistance and H Pylori Eradication

Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
0
Participant gender:
All
Summary
H pylori eradication failure with recommended triple therapy is mainly related to antibiotic resistance. However,IN VITRO culture of H pylori is uneasy and is not performed in routine practice. A molecular test of antibiotic resistance easy to perform is now available. The aim of the study was to compare eradication rates obtained with the standard treatment and with a treatment guided by the results of the molecular detection of antibiotic resistance.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Treatments:
Amoxicillin
Anti-Bacterial Agents
Antibiotics, Antitubercular
Clarithromycin
Metronidazole
Criteria
Inclusion Criteria:

- H pylori infection bacteriologically confirmed

- Age > 18 years

- Naïve patient or one failure of the first line recommended treatment

- Patient referred to one out of the centres participating in the study

Exclusion Criteria:

- H pylori positive patient with at least failure of two lies of treatment

- patients with previous adverse event with PPI, amoxicillin, clarithromycin,
levofloxacin or metronidazole

- PPI or antibiotic treatment in progressor stopped for less than 4 weeks

- patient with other severe sickness