Modulation of Remifentanil-induced Postinfusion Hyperalgesia
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
In addition to alleviate pain there is growing evidence that ยต-opioids enhance pain. This
problem is known as opioid induced hyperalgesia(OIH).The NMDA receptor is involved in opioid
induced hyperalgesia it may be possible to block OIH by cyclooxygenase inhibitors. This has
been demonstrated with parecoxib, a COX-II inhibitor, in a experimental pain model.Both COX-1
and COX-2 are expressed in the spinal cord. It would be of interest to investigate whether a
COX-1 preferring inhibitor like ketorolac also can reduce opioid induced hyperalgesic in this
experimental pain model.
Phase:
Phase 4
Details
Lead Sponsor:
Ullevaal University Hospital
Collaborators:
Rikshospitalet University Hospital University of Oslo