Modulation of Lung Injury Complicating Lung Resection

• Status: Completed
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether N-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath and lung specimens, in patients undergoing surgery to remove a portion of lung.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Imperial College London
• Collaborators: Royal Brompton & Harefield NHS Foundation Trust; Royal College of Physicians
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Elective lung resection for cancer

Exclusion Criteria:

• Age less than 18 years

• Women of child-bearing age or potential

• Known allergy to N-acetylcysteine

• Oral steroid in the preceding 1 month

• N-acetylcysteine in the preceding 1 month

• Unable to receive standardised anaesthetic approach