Overview

Modified Surface of PLGA Nanoparticles in Smart Hydrogel

Status:
Completed
Trial end date:
2022-04-16
Target enrollment:
0
Participant gender:
All
Summary
Nanoparticles containing antibiotic were prepared and incorporated in in situ gel to treat recurrent endodontic infections
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
British University In Egypt
Treatments:
Ciprofloxacin
Criteria
Inclusion Criteria:

- Root canal filled single rooted teeth with post treatment disease manifested by one or
more of the following signs and symptoms:

- History of recurrent acute and/or chronic periapical abscess

- Pain on palpation and/or percussion at least after one month of previous procedure

- Radiographic evidence of bone loss either as a new developing lesion or an increase in
the size of a pre-existing one.

Exclusion Criteria:

- Teeth that were badly broken down indicated for extraction or with difficult isolation

- Immuno-compromised patients.

- Patients with history of taking antibiotics orally.

- Periodontally affected teeth.