Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2
days/week), but the effects of modafinil on cocaine self-administration in the laboratory
have not been studied. The present study investigated the effects of modafinil maintenance on
cocaine self-administration by frequent users (4 days/week) under controlled laboratory
conditions. During this 48-day double-blind, crossover design study, the effects of modafinil
maintenance (0, 200, and 400mg/day) on response to smoked cocaine (0, 12, 25, and 50 mg) were
examined in nontreatment seeking cocaine-dependent individuals (n = 8).