Modafinil Versus Amphetamines for the Treatment of Narcolepsy Type 2 and Idiopathic Hypersomnia
Status:
Recruiting
Trial end date:
2023-02-01
Target enrollment:
Participant gender:
Summary
For diseases that cause excessive daytime sleepiness (such as narcolepsy and idiopathic
hypersomnia), there are several medications that can be used to treat sleepiness. However, it
can be difficult to decide which medication to use for a particular individual for several
reasons: 1) there are very few studies that directly compare two medications to see which
works best; 2) there are very few studies that include people with a disorder of sleepiness
called idiopathic hypersomnia.
To address this gap in knowledge, the researchers propose a randomized clinical trial
comparing modafinil and amphetamine salts in patients with narcolepsy type 2 or idiopathic
hypersomnia. All participants will either receive modafinil or amphetamine salts -- no
participant will receive placebo.
This study will evaluate which medication works better to improve sleepiness. The researchers
will also see which medication is better for other symptoms including difficulty waking up
and difficulty thinking, as well as seeing which medication causes fewer side. Finally, this
study will see if any information about patients (such as age or sleep study features)
predicts responding better to one medication or the other.