Modafinil, Sleep, and Cognition in Cocaine Dependence
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
Subjects participating in this protocol will participate in three phases: 1) pre-admission,
2) inpatient admission, and 3) follow-up. Pre-admission involves screening (detailed in
inclusion/exclusion criteria section) and one week of outpatient sleep and activity
monitoring. Inpatient admission is 16 consecutive nights on the Clinical Neuroscience
Research Unit and involves subjective and objective tests of sleep, sleepiness, attention,
and learning. During inpatient admission subjects will take modafinil or placebo. For
follow-up, subjects will return to the CNRU for one night and again participate in objective
tests of sleep, sleepiness, attention, and learning. We hypothesize that modafinil will
decrease subject and objective measures of sleepiness and will promote attention and learning
in cocaine dependent persons.