Mobilization of Endothelial Progenitor Cells Induced by Atorvastatin in Patients With Stable Coronary Artery Disease Treated With Anti-CD 34 Antibodies Coated Stents

• Status: Terminated
• Trial end date: 2021-05-13
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the extent of the mobilization of endothelial progenitor cells induced by low versus high dose atorvastatin after 4 weeks of treatment, in patients treated with anti-CD 34 antibodies coated stent.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS Policlinico S. Matteo
• Treatments: Antibodies; Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• age between 18 and 75 years

• stable angina or silent ischemia

• documented CAD

• signed written informed consent

Exclusion Criteria:

• current or recent therapy (stop < 3 months) with statins

• allergy to ASA or ticlopidine/clopidogrel

• myocardial infarction (< 3 months)

• recent significant trauma or surgical interventions (< 3 mesi)

• significant renal or hepatic diseases

• coagulative-hematological disorders

• cancer

• inflammatory diseases

• myopathy

• pregnancy (a pregnancy test will be performed in fertile women)

• severe coronary calcification, or small vessels disease (< 2.5 mm), long lesions (> 20 mm), ostial lesions, bifurcation lesions requesting treatment of the collateral vessel, multi-vessel disease requiring PCI before the completion of the study