Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis
Status:
Completed
Trial end date:
2021-08-24
Target enrollment:
Participant gender:
Summary
This proposal will prospectively assess the social, physical, and emotional recognition
function in participants with synkinesis. It will measure the effectiveness of neuromuscular
retraining therapy to improve muscle coordination compared to chemodenervation, the more
established treatment modality, in a single-blinded, randomized control trial using
clinician- and patient-reported outcomes measures. The hypothesis tested is that participants
undergoing neuromuscular retraining therapy will achieve greater improvement on clinical
outcome measures as compared to participants receiving chemodenervation.
In this clinical trial, 36 participants undergoing treatment for synkinesis will be enrolled
into one of two treatment arms: chemodenervation or neuromuscular retraining therapy.
Participants can expect to be on study for approximately 8 months.
Participants who enroll in this mixed methods investigation will be recruited from patients
of the University of Wisconsin Facial Nerve Clinic and also be enrolled in a another study
for assessment [Perception of Emotion Expression in Clinical Populations with Facial
Paralysis, IRB approval 2015-0366].