Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Observed the muscle relaxation of mivacurium in patients with liver cirrhosis.Clear of mivacurium in patients with liver cirrhosis without muscle relaxant accumulation and delayed recovery phenomenon

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tang-Du Hospital
• Collaborator: Jiangsu Nhwa Pharmaceutical Co., Ltd.
• Treatments: Anesthetics; Mechlorethamine; Mivacurium

Criteria

Inclusion Criteria:

• Patients volunteered for the clinical research and signed a written informed consent

• Experimental group patients is cirrhosis of the liver (liver function grade Child - Pugh, grade A) ready to abdominal surgery patients; The control group was no cirrhosis, ready to abdominal surgery patients

• Aged 18 ~ 60

• BMI<28kg/㎡

• The American society of anesthesiologists (ASA) class I ~ II

Exclusion Criteria:

• Systolic blood pressure ≥180 mm Hg or < 90 mm Hg, diastolic blood pressure ≥110 mm Hg or < 60 mm Hg

• Serious heart, brain, liver, kidney, lung, endocrine diseases or serious infection

• Patients with difficult airway (such as Mallampati airway class III, airway abnormalities, etc.)

• HR < 50 times/min

• The patient had a history of mental illness or chronic psychiatric drugs, chronic pain medication history

• History of alcoholism

• Patients with neuromuscular system disease

• Has a tendency to malignant hyperthermia

• The patient used to test drug allergies or other contraindications

• Over the past 30 days participated in other clinical drug research