Aim #1 To investigate the prevalence, risk and correlation of the level of sepsis with
mitochondrial dysfunction in sepsis patients Aim 1.1 To investigate the prevalence of
mitochondria dysfunction among sepsis patients Aim 1.2 To investigate the risk associated
with mitochondrial dysfunction in sepsis patients.
Aim 1.3 To investigate the association between sepsis severity (SOFA scoring system) and the
degree of mitochondrial dysfunction Aim #2 To investigate the association of mitochondrial
dysfunction in sepsis with ScvO2, lactate and ∆PCO2 Aim 3.1 To investigate the therapeutic
efficacy of steroids on the improvement mitochondrial function in sepsis patients Aim 3.2. To
investigate the efficacy of steroids on the reduction mortality rate in sepsis patients with
norepinephrine-resistant hypotension