Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of the study is to evaluate the link between insulin resistance and alterations in skeletal muscle mitochondrial redox homeostasis

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Copenhagen
• Treatments: Albuterol; Soybean oil, phospholipid emulsion; Ubiquinone

Criteria

Inclusion Criteria:

• Body mass index (BMI) ≥25 and <40 kg/m2

• Fasting plasma glucose ≥ 5.6 mmol/L or HbA1c ≥ 5.7%

• HOMA2-IR > 1.4

• VO2max <45 ml/kg/min

Exclusion Criteria:

• Treatment with >2 antidiabetic medications

• Insulin usage

• Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study

• Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study

• Smoking