Mitigating the Pro-inflammatory Phenotype of Obesity
Status:
Not yet recruiting
Trial end date:
2025-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve
activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating
blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α,
IL-6).
Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of
SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic,
hydrochlorothiazide) or a placebo.