Misoprostol for Secondary Prevention of Postpartum Hemorrhage at the Community Level in India
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
This study compares two community-level strategies: selective administration of 800 mcg
sublingual misoprostol to women at 350 mL blood loss for secondary prevention of postpartum
hemorrhage (PPH) with universal use of 600 mcg oral misoprostol at the time of delivery for
primary prevention of PPH. The study hypothesizes that at community-level births, secondary
prevention for women is non-inferior (based on clinical parameters) to universal prophylaxis
provided to women for primary prevention of PPH. This cluster-design non-inferiority trial
has the potential to inform service delivery programs on clinical outcomes, program
feasibility, cost and acceptability of two different community models of PPH care using
misoprostol.
Phase:
N/A
Details
Lead Sponsor:
Gynuity Health Projects
Collaborators:
Jawaharlal Nehru Medical College Sri B. M. Patil Medical College, Bijapur, Karnataka, India University of California, San Francisco University of Illinois at Chicago