Misoprostol for Cervical Priming Prior to Vacuum Aspiration
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
Despite of the widespread use, and extensive studies, the optimal route of administration of
misoprostol before surgical abortion remains to be defined. Following administration of 400
mcg vaginally as per clinical guidelines, the time for optimal priming seems to be 3 hours,
but the longer the interval the greater the risk or bleeding and expulsion of the uterine
contents before the surgical evacuation. Sublingual administration seems to give adequate
plasma concentration and cervical priming faster than oral or vaginal administration. This
may allow a shorter waiting time with maintained efficacy, less side effects and logistic
advantages.