Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage
Status:
Completed
Trial end date:
2020-06-30
Target enrollment:
Participant gender:
Summary
Local current protocol for cervical ripening in 1st trimester miscarriage recommends 400 µg
of misoprostol intravaginally 3 hours before uterine evacuation. This regime has been
recommended by some international guidelines . So far, there are no recent studies comparing
cervical dilatation between 400 µg of misoprostol and a reduced dose (e.g., 200 µg) for 6
hours. If cervical ripening is similar between these two regimens(i.e., 200µg regimen is not
inferior to 400µg regimen), costs reductions and lower side effects may be issued without
losing quality of cervix dilatation.