In Denmark, every 4 birth induced, most often due to prolonged pregnancy, up til 10-12 days
after term. A group (RADS) set up by the Danish Regions has recently recommended induction
with prostaglandins in tablet form (Angusta®). The recommendation is based primarily on the
results of a meta-analysis published by the Cochrane Library, where various prostaglandin
medications were compared.
Vaginal prostaglandin insert (Misodel®) have proved safe in American Studies and is
registered in Denmark for use of induction. Misodel® was not included in RADS's evaluation,
as there are only few studies on the effectiveness and side effects.
In the current study, investigators want to compare two different regimes for the induction
of primipara who use respectively Misodel® and Angusta® as the primary method. The study is
based on prospective collection of data from three divisions in Region Zealand, where
investigators primarily compare the efficacy and safety but also to evaluate women's
experience, the cost of medicine and consumption of resources in the maternity wards.