Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting
Status:
Recruiting
Trial end date:
2021-12-30
Target enrollment:
Participant gender:
Summary
Mirtazapine is a noradrenergic and specific serotonergic antidepressant. Its antagonist at
the 5HT3 receptor may help to prevent nausea and vomiting. The use of mirtazapine in the
management of nausea and vomiting has been reported in the literature, both for treatment and
premedication.
Dexamethasone, possesses analgesic, anti-inflammatory, immune-modulating, and antiemetic
effects. Dexamethasone was reported to be effective in preventing nausea and vomiting in
patients receiving cancer chemotherapy. It has also been shown to be effective in reducing
nausea and vomiting after open and laparoscopic surgical procedures.
In this randomized controlled trial, we will compare the effectiveness of both drugs in
preventing PONV in laparoscopic cholecystectomy surgery.