Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study proposes to investigate whether treatment with minocycline pre-operatively in patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce the occurence of kidney injury.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tarek M. El-Achkar
• Collaborators: Satellite Healthcare; Triax Pharmaceuticals
• Treatments: Minocycline

Criteria

Inclusion Criteria:

• Age over 18 years

• planned CABG or valvular surgery with cardiopulmonary bypass

• Serum creatinine available (within 30 days)

• Estimated GFR 15-90ml/min using the abbreviated MDRD formula (CKD stages 2-4)

Exclusion Criteria:

• Emergent or urgent surgery (to be performed within the next 36 hours)

• End stage renal disease, or GFR < 15ml/min (CKD stage 5)

• Estimated GFR>90ml/min (CKD stage 1 or no CKD)

• Ongoing infection by positive blood, urine or sputum cultures or pneumonia on CXR

• Allergy to minocycline or tetracyclines

• inability to take oral medications

• use of preoperative vasopressor agents at therapeutic doses

• Pregnant or lactating females

• Advanced liver disease by history or exam(cirrhosis, ascitis, jaundice)

• Rising creatinine meeting the definition of acute kidney injury prior to surgery

• Neurologic signs or symptoms or history of increased intracranial pressure

• current participation in another research study involving an investigational drug or device