Milrinone Versus Dobutamine in Critically Ill Patients
Status:
Completed
Trial end date:
2020-06-12
Target enrollment:
Participant gender:
Summary
The investigators are interested in determining if there is a meaningful difference between
two of the most commonly used medications used to improve the pumping function of the heart
among critically ill patients admitted to the Coronary Care Unit (CCU) at the University of
Ottawa Heart Institute (UOHI). To do this, the investigators will randomly assign patients
who are felt to require use of these medications by their treating physicians to one of the
two most commonly used agents in Canada: Milrinone or Dobutamine. Each patient will be
closely monitored by their healthcare team, and their medication will be adjusted based on
each patient's clinical status. Information from blood work (e.g. kidney and liver function,
complete blood counts, and other markers of how effectively blood is circulating in the
body), assessment of end-organ function (e.g. urine output, mentation), abnormal heart
rhythms noted on monitoring and results of imaging studies (e.g. angiogram, echocardiograms.)
will be collected for analysis. All patients will be followed for the duration of their
hospital stay at UOHI.