Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether milnacipran reduces widespread, non-joint
pain in patients with rheumatoid arthritis (RA). The investigators will conduct a
double-blind randomized crossover trial in subjects with RA to test the hypothesis that
milnacipran improves widespread, non-joint pain. The investigators will also use data from
the trial to determine whether response to milnacipran is associated with pain-modulating
mechanisms from the central nervous system. The investigators hypothesize that response to
milnacipran will be greater among patients with impaired central pain mechanisms than among
patients with intact central pain modulating mechanisms.
Phase:
Phase 4
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborators:
Forest Laboratories National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)