Midodrine for the Early Liberation of Vasopressor Support in the ICU
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Vasopressors are medications that are given intravenously to increase the blood pressure of
patients with illnesses that cause dangerous blood pressure drops. When a doctor prescribes a
vasopressor, they ask that the dose be adjusted to achieve a specific blood pressure. This
kind of medical support with intravenous (IV) vasopressors are usual treatments in intensive
care unit (ICU) settings. Oral vasopressors, such as midodrine, have been historically used
to maintain blood pressure in non-critically ill patients. In this study, the investigators
will be using midodrine to reduce the need for IV vasopressors as blood pressure improves
during the stay in the ICU
The LIBERATE pilot study will evaluate the role of midodrine for patients with low blood
pressure in the ICU. The investigators are planning on enrolling up to 60 study participants
to evaluate this question in the General Systems ICU at the University of Alberta Hospital.
Phase:
Phase 4
Details
Lead Sponsor:
University of Alberta
Collaborators:
Alberta Health Services Institute of Health Economics, Canada