Midodrine as Novel Treatment of Post-Cardiopulmonary Bypass Vasoplegic Syndrome
Status:
Terminated
Trial end date:
2018-08-08
Target enrollment:
Participant gender:
Summary
Vasoplegic syndrome (VS) is a common and serious complication of cardiopulmonary bypass (CPB)
procedures associated with a significant increase in morbidity and mortality [1-5]. VS is
defined as significant hypotension, high or normal cardiac outputs, low systemic vascular
resistance, low cardiac filling pressures, and vasopressor requirement despite adequate fluid
resuscitation following CPB [1-2]. Extensive research has been performed regarding the
pathophysiologic response to CPB and risk factors associated with VS. No safe and effective
preventive strategy has gained widespread use. Supportive care with intravenous (IV)
vasopressors has thus been adopted as standard of care [6]. The use of these medications,
while effective in the majority of patients, generally necessitates close monitoring in an
intensive care unit (ICU) setting. These patients are subject to prolonged ICU and hospital
stays, as well as the potential complications of prolonged use of central venous lines (CVL)
required to give these medications [1-3,7]. Recent studies suggest midodrine, a generic oral
vasopressor, may accelerate the decline in IV vasopressor requirements in select ICU patients
[8-10]. At our institution, the addition of midodrine to IV vasopressors for the treatment of
VS has been observed to be effective in reducing IV vasopressor duration. No literature
exists describing the use of midodrine in this patient population. The goal of this study is
to investigate the novel use of midodrine in CPB surgery complicated by VS. Ultimately, we
hope to produce literature supporting its use that may be applied on a global scale to
improve patient care