Midodrine Effect on the Mortality Rates in Septic Shock Patients

• Status: Not yet recruiting
• Trial end date: 2024-04-30
• Target enrollment: 0
• Participant gender: All

Summary

Assessing the safety and efficacy of the adjunctive use of midodrine as a vasopressor in septic shock patients by measuring the difference in the mortality rates between control and intervention groups.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Noha Mansour
• Treatments: Midodrine

Criteria

Inclusion Criteria:

• Adult aged 18 years or older diagnosed with septic shock.

• Hypotensive and require IV vasopressor for more than 24 hours.

Exclusion Criteria:

• Hypovolemic shock.

• Severe organic heart disease (ejection fraction <30 percent).

• Bradycardia (HR<50 b/m).

• Chronic kidney disease (serum creatinine >2mg/dl).

• Thyrotoxicosis.

• Pheochromocytoma.

• Known allergy to midodrine.

• Unable to administer an oral medication.