Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP
Status:
Completed
Trial end date:
2017-01-30
Target enrollment:
Participant gender:
Summary
This is a single-center, prospective, randomized, double-blinded study of consecutive
patients referred for ERCP. A recent study suggested that the addition of dexmedetomidine to
the midazolam-meperidine regimen (MMD)provided better sedative efficacy and a superior safety
profile during ERCP compared with a midazolam-meperidine regimen. Further study is warranted
to compare an MMD regimen with propofol-based regimen.
Randomization is performed by use of a computer-generated random allocations in a ratio of
1:1 in balanced blocks of 4. A separate sedating nurse, who don't participate in the study,
is the only person with knowledge of the sedation regimen. This separate nurse repeated the
injection of propofol and completed questionnaires.