Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients

• Status: Unknown status
• Trial end date: 2017-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to evaluate effects, safety and cost of midazolam used alone or sequential use of midazolam and propofol/dexmedetomidine for long-term sedation in critically ill, mechanically ventilated patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: West China Hospital
• Treatments: Dexmedetomidine; Fentanyl; Midazolam; Propofol

Criteria

Inclusion Criteria:

1. Intubated patients;

2. Age≥18 years old;

3. Anticipated Ventilation and sedation duration of at least 72 hours.

Exclusion Criteria:

1. Allergy to the study drug;

2. suspected pregnancy;

3. gross obesity;

4. Extremely unstable of circulatory system, such as systolic blood pressure less than 90 mm Hg despite plasma volume expansion and continuous infusions of vasopressors before the start of study drug infusion;

5. Uncontrolled abnormal hypertension, such as systolic blood pressure more than 180 mmHg or diastolic more than105 mmHg;

6. Heart rate less than 50 bpm;

7. Second or third degree heart block;

8. moribund state;

9. history of alcoholism or intake of anti-anxiety drugs or hypnotics;

10. chronic renal failure;

11. coma by cranial trauma or neurosurgery or unknown etiology or epileptic state;

12. History of neuromuscular disease;

13. unwillingness to provide informed consent by patients or their authorized surrogates following ICU admission.