Microorganism in Overactive Bladder Patients

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of this prospective study is to determine the incidence of mycoplasma in women with overactive bladder (OAB) symptoms and whether antibiotic therapy targeting these organisms is effective.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Azithromycin; Doxycycline

Criteria

Inclusion Criteria:

1. Women age of 20 ≤ and ≤ 80 years

2. Symptoms of urinary frequency (≥8 micturitions per 24 hours) and urinary urgency (defined as a level of 3 to 5 in a 5 point urgency scale) at least one episode a day as verified by baseline micturition diary

3. Symptoms of overactive bladder, including, urgency, frequency, and/or urinary urge incontinence for more than 3 months

4. No proven ordinary bacteria on routine urine culture or gram stain

5. Positive for one of Mycoplasma homonis, Ureaplasma Urealyticum and Chlamydia trachomatis on urethral or cervical swab

Exclusion Criteria:

1. Neurogenic bladder

2. Indwelling catheter

3. PVR ≥ 150ml

4. Interstitial cystitis

5. History of radiation therapy on pelvic area or chemotherapy

6. unable to record voiding diary

7. Pregnancy

8. Other reasons according to investigator's opinion