Microcirculatory Impairment in Patients With Leprosy

• Status: Completed
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

In this study the investigators have aimed to evaluate morphology and reactivity of cutaneous microcirculation in patients with lepromatous leprosy. Ten patients, without any other comorbidity were compared to ten controls without leprosy or any other comorbidity, using the Cytoscan® [orthogonal polarization spectral (OPS) imaging], Fourier analysis of laser Doppler signal to evaluate vasomotion (rhythmic spontaneous oscillation of arteriolar diameter) and laser Doppler flowmetry associated to iontophoresis of vasoactive substances (acetylcholine and sodium nitroprusside).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Curt Treu
• Treatments: Acetylcholine; Nitroprusside

Criteria

Inclusion Criteria:

• male patients with only lepromatous leprosy in treatment

• age between 20 and 60

• body mass index (BMI) between 18 and 35 kg/m2

• ability to follow given directions and to attend assessments and

• Fitzpatrick's Phototype I-IV

Exclusion Criteria:

• females

• arterial hypertension

• diabetes mellitus

• BMI greater than 35 kg/m2

• collagenosis

• past or present history of smoking

• age under 20 and over 60 years.