In this mechanistic pilot study in 40 patients the investigators will compare the findings in
patients treated with very early high dose statin therapy with historic controls from the
KOMPIS study published in EHJ 200925. The investigators want to assess if early high dose
statin therapy in patients treated with primary PCI:
1. reduces area of myocardial infarction, reduces volumes and improves remodelling as
assessed by MRI at 2 days and at 2 months
2. improves microcirculation (Decreased number of patients with MO) as assessed by first
pass time estimated with MRI 2 days
3. have impact on coronary blood flow as assessed by intravascular registrations and TIMI
frame count immediately after PCI
4. reduce levels of CK-MB and TnT measured as area under the curve during the hospital stay
at improves neurohumoral profile assessed by Heart Rate Variability (HRV) and
neurohormones at discharge and at 2 months follow-up
5. improves endothelial function assessed by flow mediated vasodilatation at discharge
6. alters Peak VO2 at 1 and 6 month
7. reduce levels of CRP and pro-inflammatory cytokines during index hospitalization and at
follow-up alters collagen turnover
Phase:
Phase 4
Details
Lead Sponsor:
Helse Stavanger HF
Collaborators:
Helse Vest St. Olavs Hospital University Hospital of North Norway