Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to asses the recovery of organ failure between two resuscitation protocols in severe sepsis: standard, pressure guided therapy versus a microcirculation guided therapy

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Onze Lieve Vrouwe Gasthuis
• Treatments: Dobutamine; Dopamine; Enoximone; Nitroglycerin; Norepinephrine

Criteria

Inclusion Criteria:

• age 18 years or older

• admission to the intensive care unit with severe sepsis, defined in according with a modification of the American College of Chest Physician/SCCM guidelines criteria

• intention to provide full intensive care treatment for at least 72 hours and

• written informed consent to be obtained from patient or next of kin.

Exclusion Criteria:

• haematologic malignancy

• metastatic malignancy

• AIDS with CD4 < 50 cells/mm3

• liver cirrhosis Child Pugh B & C

• pregnancy

• post resuscitation with GCS < 8 of 15 and treatment with induced hypothermia