Overview

Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke

Status:
Terminated
Trial end date:
2006-05-01
Target enrollment:
0
Participant gender:
All
Summary
The study is designed to examine the safety, tolerability, and activity of a combination of microbubbles (perflutren lipid microsphere [Definity®]) and continuous monitoring with 2 MHz transcranial Doppler ultrasound (TCD) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
ImaRx Therapeutics
Criteria
Inclusion Criteria:

- Measurable focal neurological deficit (National Institutes of Health Stroke Scale
[NIHSS] score > 4 points)

- tPA eligible

- Occlusion of the middle cerebral artery

Exclusion Criteria:

- Right to left cardiac shunt

- Uncontrolled hypertension

- Absent temporal windows