MgSO4 vs Metoclopramide for Headache in Pregnant Women
Status:
Withdrawn
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
The study will compare effectiveness of intravenous magnesium sulfate to that of intravenous
metoclopramide (Reglan®) for acute headache in pregnant women. We will randomize pregnant
women who present to our emergency department with chief complaint of headache to magnesium
sulfate 2 grams intravenously or metoclopramide 10 mg intravenously; both groups will receive
acetaminophen (Tylenol®) 1 gram orally and normal saline 1 liter intravenously. Headaches are
common during pregnancy, related to hormonal changes, altered sleep patterns and psychosocial
stressors. Common medications for headache such as non-steroidal antiinflammatories or
triptans are typically avoided during pregnancy due to concern for fetal effects. Women, and
their physicians, are often uncertain regarding available medication options with justifiable
safety profiles during pregnancy.