Mexiletine for Muscle Cramps in Charcot Marie Tooth Disease
Status:
Completed
Trial end date:
2016-12-31
Target enrollment:
Participant gender:
Summary
Charcot Marie Tooth Disease is a family of inherited peripheral neuropathies, with over 70
causative genes identified to date.1-4 Muscle cramps are frequent in CMT, affecting up to 85%
of patients with some subtypes of CMT. These cramps impact quality of life and have been
identified as an important therapeutic target for clinical trials in CMT.1-4 There is no FDA
approved treatment for muscle cramps.5 Mexiletine is a sodium channel blocker approved for
treatment of arrhythmias. As a sodium channel blocker, mexiletine offers the promise of
effective therapy for muscle cramps.