Metoprolol in Acute Myocardial Infarction. A PK/PD Study
Status:
Completed
Trial end date:
2002-04-01
Target enrollment:
Participant gender:
Summary
The objective of the study was to compare treatment with two different oral formulations of
metoprolol, metoprolol immediate release (IR) and metoprolol extended release (CR/XL) in
patients with acute myocardial infarction regarding the following:
Pharmacokinetics, peak and trough plasma concentrations and area under the plasma
concentration curve.
Pharmacodynamics, hourly means of Holter recorded heart rate. Tolerability. An open,
randomised design with two parallel groups was employed.