Total knee replacement surgery is a commonly performed and widely successful surgery to
improve mobility and decrease pain in patients suffering from severe knee arthritis. However,
in the immediate period after knee replacement, patients often experience significant pain
and nausea, which can limit early recovery after surgery. Glucocorticoids are
anti-inflammatory drugs that can reduce pain and swelling by blocking the inflammatory
process, and have already shown promise in various surgical settings, including after knee
replacement. There are different glucocorticoid formulations available, and in this
particular study, we are evaluating the effects of administering a Medrol Dose Pak, which is
a commonly available glucocorticoid taper that is administered over a short period of time
after surgery. Our hypothesis is that the administration of the Medrol Dose Pak will lead to
decreased pain, nausea, and opioid consumption in the weeks following total knee replacement.