Methylprednisolone Replacement for Dexamethasone-induced Hiccup
Status:
Withdrawn
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Dexamethasone is a potent synthetic member of the corticosteroid. It is given to cancer
patients undergoing chemotherapy to counteract emetic side effect and essential drug for the
chemotherapy-treated patients. Hiccup is common adverse effect of corticosteroid especially
on dexamethasone varying from 3% to 60% of given patients. Discontinuance of dexamethasone
relieves most hiccupping cases, but vomiting/nausea rates increase. It is not clear whether
hiccup side effect is limited to the dexamethasone only or other corticosteroid group.
Methylprednisolone, synthetic corticosteroid as similar as dexamethasone, could be considered
as antiemetic agent for the patients with receiving chemotherapy. The investigators perform
this pilot study under hypothesis that replacing dexamethasone with methylprednisolone could
maintain antiemetic role and prevent hiccup.